Effect of Knee Pain on Walking Biomechanics (NCT05670236) | Clinical Trial Compass
CompletedPhase 4
Effect of Knee Pain on Walking Biomechanics
United States55 participantsStarted 2023-01-25
Plain-language summary
The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking. The main questions it aims to answer are:
* How does unilateral knee pain affect contralateral knee joint loading during different types of walking?
* Does movement and loading change at the hips, knees, and ankles during prolonged walking in persons with painful knee osteoarthritis?
Participants will:
* Fill out questionnaires/surveys
* Complete clinical examinations
* Walking on a treadmill under different types of walking conditions
* Receive two knee injections For comparison purposes, researchers will also enroll healthy participants.
Who can participate
Age range
45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for Knee Osteoarthritis Arm:
* At least 45 years old
* Unilateral knee pain with walking that averages at least 3 out of 10 on a numeric pain rating scale
* Unilateral knee stiffness that lasts less than 30 minutes after periods of inactivity
* Unilateral symptoms on most days for at least the past 3 months
Exclusion Criteria for Knee Osteoarthritis Arm:
* History of knee replacement surgery
* Opiate use within the past 3 months
* Narcotic use within the past 3 months
* Known medical condition that affects walking mechanics, besides knee osteoarthritis
* Known medical condition that affects pain perception
* Inability to walk for 30 minutes without using an assistive device
* Body weight greater than 300 pounds
* Known allergy to adhesives
* High risk for a cardiovascular event
* Currently pregnant
* Anticoagulant use within the past 3 months
* Intraarticular knee injection within the past 3 months
* Known history of hypersensitivity to local anesthetics of the amide type
* History of lower body pain or injury, besides knee osteoarthritis, within the past 6 months
Inclusion Criteria for Healthy Arm:
* At least 45 years old
* No lower body pain or injury within the past 6 months
Exclusion Criteria for Healthy Arm:
* History of knee replacement surgery
* Opiate use within the past 3 months
* Narcotic use within the past 3 months
* Known medical condition that affects walking mechanics
* Known medical condition that affects pain perception
* Inability t…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Medial Knee Contact Forces During Walking
Timeframe: Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).
2
Change in Lateral Knee Contact Forces During Walking
Timeframe: Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).
3
Change in Patellofemoral Knee Contact Forces During Walking
Timeframe: Change from before treatment (approximately 1 week prior to the injection visit) to 30 minutes after treatment (the injection).