The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality (NCT05670184) | Clinical Trial Compass
UnknownPhase 1/2
The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality
Netherlands60 participantsStarted 2023-01-01
Plain-language summary
The goal of this study is to assess the effects of LSD on neural synchrony, prosocial behavior, and relationship quality in healthy romantic couples.
Who can participate
Age range18 Years – 35 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Written Informed Consent
* Understanding the procedures and the risks associated with the study.
* Age between 18 and 35 years old.
* Being in a steady relationship for at least 6 months.
* Proficient knowledge of the English language
* Previous experience with at least one psychedelic drug (psilocybin, LSD, mescaline, Ayahuasca, DMT, 5-MeO-DMT), but not within the past 3 months
* Absence of any major medical condition as determined by medical examination and laboratory analysis
* Absence of any major psychological condition as determined by medical examination
* Free from psychotropic medication
* Participants must be willing to refrain from taking illicit psychoactive substances during the study.
* Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day.
* Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration.
* Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion Criteria:
* History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination)
* Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks)
* Pregnancy or lactation
* Hypertension (diastolic \> 90 mmHg; systolic \> 140 mmHg)
* Current or history of psychiatric disorder …
What they're measuring
1
Neural synchrony
Timeframe: On the acute dosing test day, 1.5-2 hours after substance administration