The PROMEPHY study aims to assess differences between animal versus plant-based proteins on metabolic and physiological parameters in healthy adults. It is envisaged that the results from this study will provide important and novel insights into the potential health-benefits of regular consumption of plant-based proteins. This may enable future application in products available to the consumer.
The main objective of this study is to compare the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a plant-based protein mix with the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a milk protein isolate. In addition this study will aim to assess the impact of different protein sources on gut microbiota and proteome composition to determine the potential health impact of consumption of plant-based proteins.
Who can participate
Age range18 Years – 50 Years
SexALL
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Inclusion criteria
✓. Age ≥ 18 and ≤ 50 years
✓. Body Mass Index (BMI) ≥ 18.5 and ≤ 24.9 kg/m2
✓. Written informed consent
✓. Willingness and ability to comply with the protocol
✓. Willingness to use a method of birth control during participation in the study (women only)
✓. Judged by the investigator to be in good health
Exclusion criteria
✕. Any known ongoing medical condition that interferes significantly with absorption and digestion and/or gastrointestinal (GI) function (e.g. inflammatory bowel disease, gastroesophageal reflux disease, celiac disease, diaphragmatic hernia or diaphragmatic surgery, gastric ulcer, gastritis, gall bladder problems, pancreatitis, GI cancer, oesophageal and/or gastric surgery), in opinion of the investigator.
✕. Known cardiovascular disease, disease related to the immune system and/or the respiratory system
✕
What they're measuring
1
Amino acid Profile
Timeframe: Change from beginning (day 1) to end of each trial (day 14)