Speech Signals in Stuttering (NCT05668923) | Clinical Trial Compass
RecruitingNot Applicable
Speech Signals in Stuttering
United States600 participantsStarted 2022-09-21
Plain-language summary
The purpose of this research study is to understand how speech and language are processed in the brain. This study will provide information that may help with the understanding how speech and language are processed in children and whether there may be differences between children who stutter and children who do not stutter. This project will evaluate these neural processes for speech signals in children who stutter and control subjects through a battery of behavioral speech and language tests, electroencephalography-based (EEG) tasks, functional magnetic resonance imaging (fMRI), and computational modeling.
Who can participate
Age range
5 Years – 17 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Speaks English as primary language
* Language abilities within the typical range
* Cognitive abilities within the typical range
* No contraindications for MRI
Inclusion criteria for children who stutter:
* Presence of developmental stuttering (onset in childhood)
* No history of other communication disorder
Inclusion criteria for children who do not stutter:
* No family history of stuttering
* No history of other communication disorders (e.g., hearing impairment, language impairment, cognitive impairment/injury)
Exclusion Criteria:
* Taking medication that alters neural function
* Cognitive skills below the typical range
* Major medical illness
* Not a fluent speaker of English
* Pregnant or possibly pregnant
* Metal implants in your body (including pacemakers, neurostimulators, or other metal objects)
* Shrapnel injuries
* Ocular foreign bodies (e.g., metal shavings)
* Metal piercings that cannot be removed for the scan
* Tattoos containing iron or metal pigments
* Prone to claustrophobia
* For fMRI, those with head circumference greater than 60cm or whose weight is more than 300 pounds will be excluded due to the size of the fMRI magnet bore
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Speech Sound Identification
Timeframe: 1 Session (up to 2 hours)
2
Frequency Following Responses (EEG)
Timeframe: 1 Session (up to 30 minutes)
3
Temporal Response Functions (EEG)
Timeframe: 1 Session (up to 1 hour)
4
Blood-oxygen level dependent activation (functional magnetic resonance imaging)
Timeframe: 1 Session (up to 2 hours)
5
Multi-voxel pattern analysis (functional magnetic resonance imaging)