Dyspepsia refers to chronic or recurrent upper gastrointestinal symptoms. According to the Rome IV criteria, functional dyspepsia (FD) symptoms included meal related fullness, early satiation, epigastric pain or burning which are unexpl ained after routine investigation. FD causes substantial psychophysical burden because of its unknown etiology and high prevalence. Although FD is currently associated with local inflammation of the gastrointestinal tract and microbiota alteration, current available treatments for FD are of limited effectiveness. In view of this, many studies have applied Chinese herbal medicine in FD and achieved some therapeutic benefit. The Jing Si Herbal Tea Liquid Packet composed of eight native Taiwanese herbs (wormwo od, hickory grass, Ophiopogon japonicus, houttuynia cordata, platycodon,licorice, perilla leaves, chrysanthemum) has obtained a special export license from the Ministry of Health and Welfare. The Jing Si Herbal Tea Liquid Packet also has been registered i n clinical trials as a complementary treatment for Coronavirus disease 2019(COVID-19). The preliminary data demonstrated that the Jing Si Herbal Tea Liquid Packet may improve gastrointestinal symptoms and anxiety in patients with COVID-19. Therefore,this study aims to investigate the impact of the Jing Si Herbal Tea Liquid Packet on psychophysical burden and metabolites of microbiota in patients with FD through a double blind randomized manner.
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Change from Baseline in Pain on the Visual Analogue Scale (VAS) at day 28
Timeframe: Baseline and day 28
Change from Baseline in Pain on the Gastrointestinal symptom rating scale (GSRS) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the Pittsburgh sleep quality index (PSQI) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the Taiwanese Depression Scale (TDQ) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the State-Trait Anxiety Inventory (STAI) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the Perceived Stress Scale(PSS-10) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the Functional Dyspepsia Scale(FD) at day 28
Timeframe: Baseline and day 28
Change from Baseline on the Irritable Bowel Syndrome Scale(IBS) at day 28
Timeframe: Baseline and day 28