UnknownEarly Phase 1

Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

Egypt30 participantsStarted 2023-02-01

Plain-language summary

To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on: * Intensity of postoperative pain. * Bacterial load reduction. * levels of MMP -9 in Periapical Fluids.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

✕. Medically compromised patients.
✕. Pregnant women
✕. Patients undergoing previous endodontic treatment or analgesics and/or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
✕. Patients reporting bruxism or clenching.
✕. Teeth that show association with acute periapical abscess and swelling.
✕. Greater than grade I mobility or pocket depth greater than 5mm.
✕. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam
✕. Teeth with vital pulp.

What they're measuring

Intensity of postoperative pain

Timeframe: 6 hours post-instrumentation.

Intensity of postoperative pain

Timeframe: 12 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 24 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 48 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 6 hours post-obturation.

Intensity of postoperative pain

Timeframe: 12 hours post-obturation

Intensity of postoperative pain

Timeframe: 24 hours post-obturation

Intensity of postoperative pain

Timeframe: 48 hours post-obturation

Trial details

NCT IDNCT05666089

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-02-01

View on ClinicalTrials.gov More Intracanal Medication trials

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

✕. Medically compromised patients.
✕. Pregnant women
✕. Patients undergoing previous endodontic treatment or analgesics and/or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
✕. Patients reporting bruxism or clenching.
✕. Teeth that show association with acute periapical abscess and swelling.
✕. Greater than grade I mobility or pocket depth greater than 5mm.
✕. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam
✕. Teeth with vital pulp.

What they're measuring

Intensity of postoperative pain

Timeframe: 6 hours post-instrumentation.

Intensity of postoperative pain

Timeframe: 12 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 24 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 48 hours post-instrumentation

Intensity of postoperative pain

Timeframe: 6 hours post-obturation.

Intensity of postoperative pain

Timeframe: 12 hours post-obturation

Intensity of postoperative pain

Timeframe: 24 hours post-obturation

Intensity of postoperative pain

Timeframe: 48 hours post-obturation