CompletedNot Applicable

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)

China90 participantsStarted 2023-01-07

Plain-language summary

This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in patients undergoing carotid endarterectomy were evaluated using TCD techniques to investigate the specific mechanisms of the three vasopressors on cerebral blood flow and oxygen metabolism in brain tissues.

Who can participate

Age range40 Years – 80 Years

SexALL

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Inclusion criteria

✓. age 40-80 years.
✓. elective carotid endarterectomy.
✓. Signed informed consent

Exclusion criteria

✕. American Society of Anesthesiologists physical status classification (ASA) IV - VI.
✕. renal failure (estimated glomerular filtration rate less than 60 ml/min.m2).
✕. cardiac arrhythmias.
✕. Allergy to ephedrine, phenylephrine or norepinephrine, gadobutrol.
✕. patients with preoperative TCD suggesting poor temporal window signal.
✕. patients with severe carotid artery stenosis with no flow signal detected by TCD
✕. Patients with tandem lesions of carotid artery stenosis

What they're measuring

Changes in middle cerebral artery blood velocity

Timeframe: 10 minutes after entering the operating room; 10 minutes after intubation ;5 minutes after administration of vasopressors

Trial details

NCT IDNCT05665881

SponsorBeijing Tiantan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-09-24

View on ClinicalTrials.gov More Carotid Endarterectomy trials