CompletedNot Applicable

Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)

Indonesia30 participantsStarted 2022-10-01

Plain-language summary

This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels in patients undergoing general anesthesia surgery

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18-65 years who undergo surgery under general anesthesia * ASA physical statuses 1 and 2 * Sepsis Exclusion Criteria: * Refuse to participate * Diabetes mellitus, experience shock sepsis or lactic acidosis * Have a history of hypersensitivity (allergy) to thiamine * Thiamine deficiency * Take immunomodulatory drugs, antiplatelet or anticoagulants surgery duration \> 6 hours, and thiamin regularly * They experience massive bleeding and receive blood transfusions preoperatively, intraoperatively, or postoperatively

What they're measuring

Glucagon Level

Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose

ROS Level

Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose

Trial details

NCT IDNCT05663164

SponsorUniversitas Sumatera Utara

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-11-30

View on ClinicalTrials.gov More Sepsis trials