CompletedNot Applicable

The Effect of Blood Carboxyhemoglobin Levels on Total Antioxidant (Tas), Total Oxidant(Tos), Hypoxia Inducible Factor-1a (hif1a) During Low-flow and Normal-flow Anesthesia

Turkey (Türkiye)130 participantsStarted 2023-01-02

Plain-language summary

In contrast to toxic CO concentrations, low-dose CO acts as a signaling molecule and can exert many complex cytoprotective effects. Therefore, the effects of low-dose CO are being investigated and developed as a new treatment method for use in various disease processes. However, these studies are mostly in vivo and in vitro studies and clinical studies have not reached a sufficient number. In this study, the effect of subclinical COHB levels on biomarkers such as TAS, TOS, HIF-1α will be evaluated.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-70 years old * ASA I-II * none-smoking * without systemic disease * elective surgery with general anesthesia Exclusion Criteria: * over 70 years old * with cardiovascular disease * with respiratory system disease * liver or kidney disease * pregnant or nursing female patient * those who do not want to participate * patient with multi-trauma * ASA III and above * emergency surgery * surgery with blood transfusion * smokers

What they're measuring

Cohb

Timeframe: t1: first hour of surgery

tas

Timeframe: t1: first hour of surgery

tos

Timeframe: t1: first hour of surgery

hif-1α

Timeframe: t1: first hour of surgery

Trial details

NCT IDNCT05661045

SponsorAtaturk Training and Research Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-02

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