RecruitingNot Applicable

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

United States144 participantsStarted 2024-06-18

Plain-language summary

The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.

Who can participate

Age range

55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * • Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min); * \>55 yrs of age * Mild cognitive impairment (18-26 on the MOCA) * ability to undergo an MR * no history of major head trauma (No head trauma/concussion with loss of consciousness) * Speaks, reads, writes English Exclusion Criteria: * • Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18 * Participating in a supervised exercise program with intent to increase fitness levels 3 days/week, * Requires assistive ambulation * Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease * Class III-IV heart failure * History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and recent systemic/pulmonary embolus * Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg * Any unforeseen illness or disability that would preclude cognitive testing or exercise training * One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only) * Any self-reported major psychiatric disorders requiring medical therapy (e.g. sc…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Executive Function from baseline

Timeframe: Change from baseline at 6 months

Change in processing speed from baseline

Timeframe: Change from baseline at 6 months

Change in attention/information processing from baseline

Timeframe: Change from baseline at 6 months

Change in Learning and Memory short recall

Timeframe: Change from baseline at 6 months

Change in Learning and Memory long recall

Timeframe: Change from baseline at 6 months

Change in Learning and Memory learning slope

Timeframe: Change from baseline at 6 months

Change in Learning and Memory recognition memory discrimination

Timeframe: Change from baseline at 6 months

Trial details

NCT IDNCT05655325

SponsorColumbia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02-01

Contact for this trial

Ulf G Bronas, PhD

212-305-0750 ub2154@cumc.columbia.edu

View on ClinicalTrials.gov More Mild Cognitive Impairment trials

Who can participate

Age range

55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Executive Function from baseline

Timeframe: Change from baseline at 6 months

Change in processing speed from baseline

Timeframe: Change from baseline at 6 months

Change in attention/information processing from baseline

Timeframe: Change from baseline at 6 months

Change in Learning and Memory short recall

Timeframe: Change from baseline at 6 months

Change in Learning and Memory long recall

Timeframe: Change from baseline at 6 months

Change in Learning and Memory learning slope

Timeframe: Change from baseline at 6 months

Change in Learning and Memory recognition memory discrimination

Timeframe: Change from baseline at 6 months