CompletedNot Applicable

Histological Profiles of Lung Allograft Transbronchial Biopsies and Clinical Outcomes After Lung Transplantation

498 participantsStarted 2010-02-01

Plain-language summary

Lung transplantation is the only curative treatment for individuals with end-stage lung disease. Understanding the lung allograft's histological lesions, which is key for the patient management, remains difficult because of the multiplicity of lesions associated with graft outcome and their interpenetration. The goal of this observational study is to identify clusters of histological lesion on transbronchial biopsies in Lung transplant recipient prospective cohort. The main question\[s\] it aims to answer are: * what are the different pattern of histological lesion? * what are the graft outcome associated with the different clusters?

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * i) age greater than 18 years, * ii) single or bilateral lung transplantation, * iii) having at least one transbronchial biopsy available for analysis * iv) consent their clinical data to be used for research Exclusion Criteria: • Biopsies with at least one missing value in the standardized clinical report were excluded

What they're measuring

graft loss resulting in death or re-transplantation and all-cause mortality

Timeframe: 118 months

Trial details

NCT IDNCT05655208

SponsorParis Translational Research Center for Organ Transplantation

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-11-30

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