Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Ath… (NCT05653505) | Clinical Trial Compass
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Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis
China160 participantsStarted 2023-01-01
Plain-language summary
The purpose of this registry is to evaluate the safety and efficacy of RIC for patients with symptomatic intracranial atherosclerotic stenosis (sICAS) undergoing endovascular therapy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patient admitted from Jan. 1st 2023 to Jan. 1st 2025;
. Age ≥ 18;
. Intracranial atherosclerosis stenosis measured as ≥70% by digital subtraction angiography or by other noninvasive methods, such as transcranial doppler, computed tomography angiography, or magnetic resonance angiography;
. A history of stroke/transient ischemic attack attributed to ICAS;
. Verbal and written informed consent is provided at the time of admission by patients or their legally authorized representatives.
Exclusion criteria
. Stenosis of other causes;
. Prior ipsilateral stroke with residual deficits;
. Uncontrolled hypertension (defined as systolic blood pressure ≥200 mm Hg despite medications at enrollment);
. Peripheral vascular disease (especially subclavian arterial and upper limb artery stenosis or occlusion).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial combines a technique called remote ischemic conditioning with endovascular stenting for intracranial artery narrowing — can you explain what the remote ischemic conditioning part actually involves, and whether you think that combination makes sense for my specific situation?
2The trial is checking for new brain lesions on a special MRI scan within 48 hours after the stenting procedure — does that mean there's a known risk of small strokes or brain injury from this type of procedure, and how does that risk compare to my risk of stroke if I don't have the procedure at all?
3The recruitment status for this trial is listed as unknown, which may mean it's not actively enrolling right now — do you know whether this study is still open and accepting patients, and if not, are there similar trials I should look into?
4Since this trial tracks clinical adverse events for a full 12 months after the stenting, what kinds of complications or setbacks would I need to be prepared to watch for and report during that follow-up period?
5Before considering this trial, should I explore whether standard medical management alone — like blood thinners or statins — might be a reasonable first step for my intracranial artery narrowing, rather than going straight to an endovascular procedure?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The presence of ≥1 new brain lesions on DWI within 48 hours after endovascular stenting
Timeframe: 48 hours
2
Incidence of clinical adverse events within 12 months after endovascular stenting