REVErsing Airway Remodelling With Tezepelumab

Inclusion Criteria: Admitted to screening visit: * Minimum age: 18 * Maximum age: 85 * Able to perform an inspiratory and expiratory thoracic computed tomography (CT) scan, plus a nasal CT * In stable condition for CT scan * Physician-diagnosed asthma according to GINA criteria * Disease with clinical impact: at least 1 severe or 2 moderate exacerbations in the previous 12 months despite treatment according to the best standards of care * Maximal inhaled therapy comprising high dose ICS and at least a second controller according to GINA Based on results of screening visit and run-in: * Post-bronchodilator forced expiratory volume in 1 second (FEV1) predicted values must be at 25-90% * Asthma Control Questionnaire 6 (ACQ6) \> 1.5 * Oral corticosteroid maintenance therapy (if used) ≤7.5 mg/day * On CT scan, the average percentage wall area index at the B1 and B8 bronchi (generation 3, 4, 5) is \>65% Exclusion Criteria: * CT abnormalities evocative of any respiratory condition other than asthma * Treatment regimen discordant with best practices * Pulmonary disease other than asthma requiring treatment during the previous 12 months * A smoking history of \>20 pack years * Receipt of any marketed or investigational biologic agent§ within 3 months or 5 halflives (whichever is longer) prior to randomization or receipt of any investigational non biologic agent within 30 days or 5 half-lives (whichever is longest) prior to randomization or receipt of live attenuated vaccines 30 …