CompletedNot Applicable

Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?

Canada20 participantsStarted 2022-12-16

Plain-language summary

Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with heart failure with left ventricle ejection fraction of 40% * Heart failure of ischemic or dilated etiology * Ambulatory patient with a NYHA functional class of II-III; * Stable symptoms and no change in medical therapy in the last month. Exclusion Criteria: * Diabetes * Patients treated with any SGLT2i; * Chronic kidney disease * Acute coronary syndrome in the last 3 months; * Use of parenteral inotropic agents; * Persistent or permanent atrial fibrillation or atrial flutter; * Presence of pacemaker or defibrillator; * Medical condition that causes malabsorption of the test material; * Under ketogenic diet, or using exogenous ketone supplements * Use of nicotinamide adenine dinucleotide (NAD) precursor supplements

What they're measuring

Left ventricle ejection fraction by cardiac MRI under acute intake of exogenous ketone salt compared with exogenous carbohydrate placebo in heart failure patients.

Timeframe: 15 minutes

Trial details

NCT IDNCT05651529

SponsorUniversité de Sherbrooke

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-16

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