The goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin resistance. The main question\[s\] it aims to answer are: * Does taking the ketone supplement reduce appetite and improve cognition? * How does the ketone supplement alter metabolism and cardiovascular function? Participants will be asked to consume a randomly assigned ketone ester supplement or a placebo and testing will be done to see how the supplement affects the following compared to a placebo: * appetite, * cognition, * metabolism * cardiovascular function Researchers will compare individuals with obesity and insulin resistance to individuals with normal weight and no insulin resistance to see if the ketone supplement affects groups differently.
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Blood pressure
Timeframe: Baseline (pre-ingestion)
Blood pressure
Timeframe: 30 minutes post ingestion
Blood pressure
Timeframe: 45 minutes post ingestion
Blood pressure
Timeframe: 60 minutes post ingestion
Blood pressure
Timeframe: 75 minutes post ingestion
Blood pressure
Timeframe: 90 minutes post ingestion
Blood pressure
Timeframe: 105 minutes post ingestion
Heart Rate
Timeframe: Baseline (pre-ingestion)
Heart Rate
Timeframe: 30 minutes post ingestion
Heart Rate
Timeframe: 45 minutes post ingestion
Heart Rate
Timeframe: 60 minutes post ingestion
Heart Rate
Timeframe: 75 minutes post ingestion
Heart Rate
Timeframe: 90 minutes post ingestion
Heart Rate
Timeframe: 105 minutes post ingestion
Heart Rate Variability
Timeframe: Baseline (pre-ingestion)
Heart Rate Variability
Timeframe: 45 post ingestion
Cardiac Baroreflex Sensitivity
Timeframe: 105 minutes post ingestion
Hunger - Visual Digital Analog Scale (0-100)
Timeframe: Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion
Fullness - Visual Digital Analog Scale (0-100)
Timeframe: Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion
Desire to eat - Visual Digital Analog Scale (0-100)
Timeframe: Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion
Prospective consumption of food - Visual Digital Analog Scale (0-100)
Timeframe: Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion
Thirst - Visual Digital Analog Scale (0-100)
Timeframe: Baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion
Stroop Test - Digital Cognitive Function Test
Timeframe: Baseline, 75 minutes
Go/No-go Test - Digital Cognitive Function Test
Timeframe: Baseline, 75 minutes
Task Switching Task - Digital Cognitive Function Test
Timeframe: Baseline, 75 minutes
Number Back Test - Digital Cognitive Function Test
Timeframe: Baseline, 75 minutes
Digit Span Test - Digital Cognitive Function Test
Timeframe: Baseline, 75 minutes