Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Fu… (NCT05649657) | Clinical Trial Compass
CompletedNot Applicable
Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function
Taiwan34 participantsStarted 2020-07-01
Plain-language summary
To assess the efficacy of a 6-month lifestyle intervention in patients with end-stage renal disease(ESRD), we plan to conduct a self-controlled clinical trial. 34 participants receiving chronic HD will be enrolled. Each participant will go through three phases: 3-month control, 6-month intervention, and 3-month maintenance. No intervention will be performed in the control and maintenance phases. The lifestyle intervention will comprise care from a multidisciplinary team, including a nephrologist, nurse practitioner, physiatrist, and dietitian. The exercise training component is an in-hospital supervised training 2\~3 times weekly for 6 months. Cyclic aerobic and resistance training will be performed. Assessment will be performed every three months and 5 times in total, including cardiopulmonary exercise testing, isokinetic quadriceps strength testing, hand grip strength, body composition analysis, Chinese Kidney Disease and Quality of Life questionnaire, self-recorded physical activity, and Mini Nutritional Assessment. The aim of this study is to assess the efficacy of a lifestyle intervention in patients with chronic kidney disease (CKD) on physical fitness, quality of life, and immunity. It is hypothesized that the lifestyle intervention will elicit a significant benefit in the aforementioned parameters and will last until the maintenance phase.
Who can participate
Age range
20 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* patients who are on HD for longer than 6 months
* under the permission of their nephrologist
* adequately dialyzed (most recent Kt/V \> 1.2) and stable during dialysis in the past 3 months
Exclusion Criteria:
* occurrence of hyperkalemia in the past 3 months
* comorbid medical, physical, and mental conditions that contraindicate exercise
* unstable cardiac conditions (eg, unstable angina, heart failure or symptomatic severe aortic stenosis, etc.)
* disabling orthopedic and neuromuscular diseases
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial looked at lifestyle intervention for people with end-stage renal disease and measured peak oxygen consumption — can you help me understand what that means for my kidney disease, and whether improving my fitness level is something we should be actively working on together?
2Since this trial is already completed, have the results been published yet, and if so, what did they find about how exercise or lifestyle changes affected inflammation markers like cytokines in people with ESRD?
3The trial tracked inflammatory cytokines as a key outcome — does my current level of inflammation put me at a point where a structured lifestyle program might make a meaningful difference, or are there other priorities we should address first?
4This study focused on people with end-stage renal disease specifically — given where I am in my kidney disease, would a supervised lifestyle or exercise program be safe for me, or are there risks I should be aware of before trying something like this?
5Are there existing lifestyle or rehabilitation programs similar to what this trial tested that I could access right now, or would it make more sense to wait and see what this completed trial's findings recommend?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.