Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm… (NCT05649384) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
United States, Australia, Austria64,374 participantsStarted 2020-12-01
Plain-language summary
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. Both algorithms are recommended by the European Society of Cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm.
Currently, most emergency departments worldwide use the 0/3-hour troponin algorithm. Cardiac troponin (cTn) is a heart-specific biomarker which indicates damage of the heart muscle and which increases after a heart attack. In the 0/3-hour algorithm, the amount of troponin in the bloodstream is measured with a high-sensitivity assay at admission and 3 hours thereafter. Likewise, the 0/1-hour algorithm means that the blood sample in which the troponin is measured is collected at admission and 1 hour later. Since recent clinical studies suggest that the 0/1-hour algorithm is superior to the 0/3-hour algorithm, many hospitals consider switching to the 0/1-hour algorithm.
The aim of this study is to assess how feasible the time-saving 0/1-hour algorithm would be in reality and whether it provides the same accuracy and safety in the diagnosis of myocardial infarction as the current practice the 0/3-hour algorithm.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18 and above
* Presentation with acute non-traumatic acute chest pain to the emergency department
* Suspicion of acute myocardial infarction
Exclusion Criteria:
* Terminal kidney failure requiring dialysis
* Cardiac arrest
* Cardiogenic shock
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing a rapid chest pain triage method called the ESC 0/1-hour algorithm — can you explain how that approach differs from the standard way my chest pain would normally be evaluated in the emergency department, and whether it might apply to my situation?
2The trial is tracking whether patients experience death or a new heart attack within 30 days of their ER visit — based on what's been learned so far, does this triage approach appear to be as safe as the standard process for someone with my type of chest pain?
3One of the main things this study is measuring is how quickly patients can be discharged or moved out of the ED — does a faster discharge timeline concern you at all given my specific symptoms and test results?
4Since this trial is no longer actively enrolling, what does the evidence from studies like this one tell you about how my chest pain should be evaluated and triaged right now, and is the 0/1-hour algorithm something this hospital already uses?
5If this rapid triage method were used in my care, what would happen if my results fell into an unclear or intermediate category — would I still be monitored closely, or could I be sent home sooner than might feel safe to me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Composite of all-cause mortality or new AMI (type 1) occurring within 30 days of index presentation
Timeframe: 30 days
2
Time from ED presentation to ED discharge or transfer