Structuring of a Lung Cancer Screening Program Including Clinical, Radiological and Biological Phenotyping Useful for the Development of Individualized Risk Prediction Tools: PREVALUNG ETOILE

Inclusion Criteria: Age 45- 75 years and * Medical follow-up for a smoking-related pathology : * atheroma * chronic obstructive pulmonary disease / emphysema * history of non evolving cancer \> 5 years among: ENT, lung, breast, cervical, excreto-urinary cervix, excreto-urinary tract, bladder, esophagus, stomach, pancreas, liver, kidney, chronic myeloid leukemia chronic myeloid leukemia, * daily smoking for at least 10 years prior to the disease Or NLST inclusion criteria: * Age 55 - 74 years * Cumulative smoking ≥ 30 pack-years * active or quit for less than 15 years Or Inclusion criterion in NELSON: * Age 50-75 years * Smoking: * \> 15 cigarettes/D for more than 25 years or * \> 10 cigarettes /D for more than 30 years * Active smoking or cessation \< 10 years Or New American recommendations : * Age 50 - 80 years * Smoking ≥20 PA * Active or weaned \<15 years Exclusion Criteria: history of cancer \< 5 years (except carcinoma in situ of the uterine cervix, basal cell skin carcinoma basal cell carcinoma of the skin and prostate cancer with undetectable PSA) * Symptoms of lung cancer (unintentional weight loss \> 7 kg in 1 year, hemoptysis) * known history of pulmonary nodule with specialized follow-up * history of pulmonary fibrosis or pulmonary hypertension * patient under guardianship or curatorship * active pulmonary parenchymal infection * severe cardiac or respiratory insufficiency (rest dyspnea) * patient not affiliated to the social security system (beneficiar…