Sickle cell disease (SCD) is an autosomal recessive genetic disorder linked to a single mutation on beta-globin chains. This leads to red blood cell deformation and chronic hemolysis which can result in vaso-occlusive events, anemia and vasculopathy. Pathophysiology is incompletely understood, and beyond red blood cell's abnormalities this involves hemostasis and innate immunity. The aim of our study is to describe the mechanisms of thrombo-inflammation during the vaso-occlusive crisis (VOC) in adults with sickle cell disease.
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To evaluate mechanisms of platelet activation in the thrombo-inflammation process during a vaso-occlusive crisis.
Timeframe: First 48h of hospitalization
To evaluate mechanisms of platelet activation in the thrombo-inflammation process during a vaso-occlusive crisis.
Timeframe: Day 13 (+/- 2 days)
To evaluate mechanisms of platelet activation in the thrombo-inflammation process during a vaso-occlusive crisis.
Timeframe: At day 60 (+/- 2 days)