WithdrawnPhase 1

Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.

Stopped: Study was unable to obtain IRB approval because CBD was not legal in Nebraska at that time.

0Started 2020-05-14

Plain-language summary

This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient. Unfortunately, periodontology has not yet discovered a therapy that will predictably treat local inflammation in patients who are at risk for further pocketing, bleeding on probing, bone loss and ultimately, tooth loss. Although CBD has been patented in various forms since the 1940s, its acceptance and availability to patients has only recently expanded. Marketing of CBD to periodontal patients as a means to control inflammation is commonplace online and in CBD-specific shops. In determining if CBD is a successful supplement to conventional periodontal inflammation control therapies, millions of patients could benefit from this treatment.

Who can participate

Age range40 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * diagnosis of chronic moderate-advanced periodontitis * one 6-9 mm interproximal probing depth * overall good systemic health * history of regular PMT Exclusion Criteria: * systemic disease that significantly affect periodontal inflammation and bone turnover * surgical periodontal therapy in the past year * pregnant/breast-feeding females.

What they're measuring

Clinical Attachment Level

Timeframe: baseline

Clinical Attachment Level

Timeframe: 6 months

Trial details

NCT IDNCT05646459

SponsorUniversity of Nebraska

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-05-14

View on ClinicalTrials.gov More Periodontitis, Adult trials