Effect of Gradually Increasing Force Magnitude on the Rate of Canine Retraction Randomized Contro… (NCT05643443) | Clinical Trial Compass
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Effect of Gradually Increasing Force Magnitude on the Rate of Canine Retraction Randomized Controlled Trial
Egypt17 participantsStarted 2022-12
Plain-language summary
Therefore the aim of the current randomized controlled clinical trial is to investigate the effect of gradually increasing force magnitude versus constant force magnitude on the rate of tooth movement in a canine retraction model, furthermore investigate the effect of the two force systems on the ratio of cytokines and the pain experienced by the patient.
Research question:
In adult orthodontic patients requiring bilateral maxillary canines retraction, will gradually increasing force magnitudes accelerate the rate of canine retraction in the experimental side when compared to the control side?
Who can participate
Age range
16 Years – 30 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Males and Females with an age ranging between 16-30 years (Adult patients since cooperation increases with age) (17).
. Malocclusion that requires extraction of the maxillary first premolars and canines retraction with moderate anchorage.
. Full permanent dentition with exception of the third molars.
. Good oral hygiene and periodontal condition (Probing depth\< 4 mm in all teeth), since the periodontal condition affects the amount and type of tooth movement.
. Absence of untreated caries which may worsen during the study time.
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Rate of canine retraction
Timeframe: 4 months
2
change on the Cytokine levels in the gingival crevicular fluid
. Patients suffering from any congenital or hereditary diseases.
. Smoking or any systemic diseases.
. Chronic use of any medications including antibiotics, phenytoin, cyclosporine, anti-inflammatory drugs, systemic corticosteroids, and calcium channel blockers. All the above factors affect the rate of tooth movement