UnknownPhase 4

Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment

Canada90 participantsStarted 2023-07-01

Plain-language summary

This study aims to analyze the immune profiles of patients with Chronic Rhinosinusitis with Nasal polyps (CRSwNP) with and without asthma before and after Mepolizumab. A group of participants with CRS without nasal polyps (CRSsNP) with asthma will be included to compare their immune profiles to CRSwNP.

Who can participate

Age range19 Years

SexALL

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Inclusion criteria

✓. Are over the age of 19.
✓. Patients with CRSwNP with or without asthma:
✓. Patients with CRSsNP with asthma:
✓. Females of childbearing potential must commit to using an acceptable method of birth control for the duration of the study and they must have a negative urine pregnancy test at each study visit.

Exclusion criteria

✕. Current or past sinonasal or bronchial tumours
✕. Subjects who have been treated with oral antibiotics in the past month prior to surgery.
✕. Subjects with known immunodeficiency
✕. Subjects with known autoimmune disease
✕. Smoking history; current or former smokers.
✕. Prior lung transplants
✕. Subjects with parasitic (helmintic) infection
✕. Subjects with hypersensitivity; with allergy/intolerance to a monoclonal antibody or biologic

What they're measuring

Compare the immune profile in CRSwNP patients with and without asthma (before and after Mepolizumab treatment), and with asthmatic CRSsNP patients.

Timeframe: 24 weeks

Trial details

NCT IDNCT05642806

SponsorSt. Paul's Sinus Centre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-30

Contact for this trial

Atenea Pascual, PhD

604-806-9926 apascual@providencehealth.bc.ca

View on ClinicalTrials.gov More Chronic Rhinosinusitis With Nasal Polyps trials