Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of … (NCT05641766) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
United States50 participantsStarted 2025-08-31
Plain-language summary
The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.
Who can participate
Age range21 Years – 65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Cannabis use at least once in the past 12 months
* No cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test day
* Good physical and mental health
Exclusion Criteria:
* Cannabis naïve individuals
* Lifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion.
* Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completion
* Major current or recent stressors
* Positive urine drug test
* Contraindication for Magnetic Resonance Imaging
* Treatment with psychotropic medication as per discretion of the PI
* IQ less than 80
* Weight exceeding 166kg
* Diagnosis of major psychotic or manic disorder in first-degree relatives.
What they're measuring
1
Changes in brain dynamics during the Sternberg Working Memory Task
Timeframe: Baseline and starting at +15 minutes after start of IV THC or placebo administration