Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

Inclusion Criteria: * Patients who speak English and are willing to sign the consent form * Patients with acute early postoperative infection (symptoms ≤ 4 weeks from surgery; symptoms \< 4 weeks in duration) and acute hematogenous infection (greater than 4 weeks from surgery; symptoms \< 3 weeks in duration) of a primary total knee or total hip arthroplasty, defined as: * A sinus communicating with the prosthesis OR * Two positive cultures obtained from the prosthesis OR * 4 of 5 criteria: Elevated ESR (\> 30mm/hr) and CRP (\> 10mg/L); Elevated synovial leukocyte count (\>3000 cells/μL) or change of ++ on; leukocyte esterase strip; Elevated synovial neutrophil percentage (\> 80%); One positive culture; Positive histological analysis of periprosthetic tissue (\> 5 neutrophils per high; Power field in 5 high power fields x 400). * OR Patient with an acute infection diagnosed clinically by an orthopedic surgeon treated with DAIR Exclusion Criteria: * Patients with a chronic PJI, defined as: presentation of symptoms \> 4 weeks in duration. * Revision surgery or previous two-stage reimplantation.