Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
France160 participantsStarted 2022-01-26
Plain-language summary
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
Who can participate
Age range55 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Aged 55-75 years
* Right-handed as assessed by the Edinburgh Inventory
* Health Insurance
* Able to follow experimental instructions
* Consent
* Independent in daily life activities as assessed by Katz autonomy score, ADL and IADL
Inclusion criteria (MCR group specific)
* Reduced gait speed as assessed by the 4m or 10m walk test value compared to normative values (Bohannon \& Williams Andrews, 2011)
* Subjective cognitive complaint as assessed by dedicated questionnaire
* Subnormal cognitive function as assessed by the Montreal Cognitive Assessment (MoCA) test with score \> 23
Inclusion criteria (Controls group specific)
\- Subnormal cognitive function as assessed by the Montreal Cognitive Assessment (MoCA) test with score \> 23
Exclusion criteria:
* Uncorrected visual or auditive deficits not allowing the realization of the experiment
* Evolutive disease (such as cancer)
* Active depression
* Neurological or psychiatric antecedent
* Neuromuscular impairment
* BMI \< 35
* Counter-indication to MRI
What they're measuring
1
Prediction accuracy to detect MCR participants will be computed using Machine learning