CompletedPhase 4

Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial

Norway1,020 participantsStarted 2022-12-13

Plain-language summary

1. To investigate and compare the affective short-term effects of opioid drugs: morphine, oxycodone and fentanyl, administered to the patients before the induction of general anesthesia. 2. Charting opioid use after surgery in patients treated at hospitals in Norway 3. Identify predictors for postoperative opioid use and persistent pain

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

. Known allergic reactions to morphine, oxycodone,or fentanyl. Known allergic reactions to any of the incredients described in the SPC, pt 6.1.
. Severe chronic obstructive lung disease,
. Cor pulmonale,
. Severe bronchial asthma,
. Severe respiratory failure with hypoxemia and hypercapnia
. Moderate to severe hepatic impairment,
. Moderate to severe kidney failure
. Acute abdomen

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Anxious

Timeframe: 8-10 minutes

Relaxed

Timeframe: 8-10 minutes

Pain level

Timeframe: 8-10 minutes

Good

Timeframe: 8-10 minutes

Dizzy

Timeframe: 2-4 minutes

Sedated

Timeframe: 2-4 minutes

Feeling high, Numeric rating scale 0 -10

Timeframe: 2-4 minutes

Euphoric

Timeframe: 2-4 minutes

Trial details

NCT IDNCT05639712

SponsorOslo University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-27

View on ClinicalTrials.gov More Opioid Use trials

Plain-language summary

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

. Known allergic reactions to morphine, oxycodone,or fentanyl. Known allergic reactions to any of the incredients described in the SPC, pt 6.1.
. Severe chronic obstructive lung disease,
. Cor pulmonale,
. Severe bronchial asthma,
. Severe respiratory failure with hypoxemia and hypercapnia
. Moderate to severe hepatic impairment,
. Moderate to severe kidney failure
. Acute abdomen