The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients

Inclusion Criteria: * Aged ≥18 years * Mechanically ventilated for more than 48 hours * Fulfilling readiness-to wean criteria * Written informed consent from the patient or his/her legal representative Exclusion Criteria: * Patients with risk factors for laryngeal oedema and a negative cuff leak test (indicating upper airway obstruction with need for steroid treatment) * Planned replacement of the endotracheal tube for a tracheostomy * Terminal illness