Not Yet RecruitingPhase 2

NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

26 participantsStarted 2026-12

Plain-language summary

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Who can participate

Age range19 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * participants must have had a traumatic spinal cord injury at least one year ago * regular bowel care routine * can communicate in English Exclusion Criteria: * cauda equina or conus lesions * currently use ventilator * colostomy, or do not perform regular bowel care * skin breakdown (pressure sores) * cannot communicate in English * under 19 years old * possibly or certainly pregnant * medical/psychiatric condition or substance abuse that is likely to affect ability to complete study * currently using medications containing PDE-5 inhibitors * currently using medications containing GTN * allergy to GTN

What they're measuring

Blood pressure change during bowel care

Timeframe: Time Frame: Measured continuously during bowel care (approximately one hour) on two occasions within 28 days.

Trial details

NCT IDNCT05635851

SponsorSimon Fraser University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-02

Contact for this trial

Victoria Claydon, Dr.

778-782-8513 victoria_claydon@sfu.ca

View on ClinicalTrials.gov More Spinal Cord Injuries trials