CompletedNot Applicable

Central Sensitization and Physical Activity in Adolescents With HSD/hEDS

Sweden100 participantsStarted 2022-11-25

Plain-language summary

Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear. The goal of this study is to better understand pain and its impact on function in the daily activities of adolescents with Hypermobility Spectrum Disorder and/or hypermobile Ehlers-Danlos Syndrome. This study will explore the presence of the pain sensitivity status after physical exercise as well as movement behaviour in adolescents with HSD/hEDS compared to a healthy control group.

Who can participate

Age range13 Years – 17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria for the HSD/hEDS group: * Able to read and understand Swedish * Diagnosed with HSD or hEDS Exclusion criteria for the HSD/hEDS group: * Pregnancy and one year postpartum. * Other syndromes with hypermobility such as the Marfan syndrome, Osteogenesis Imperfecta or other types of EDS. * Co-morbidity with neurological disorders Inclusion criteria for the control group: * Able to read and understand Swedish * Healthy * Pain free at time of investigation (Numerical Rating Scale score \<3/10). Exclusion criteria for the control group: * Pregnancy and one year postpartum. * Past or present signs of rheumatic, neurologic, musculoskeletal, metabolic diseases. * Chronic pain.

What they're measuring

Pressure Pain thresholds, primary and secondary hyperalgesia

Timeframe: Baseline, pre-intervention

Change of Pressure Pain thresholds, exercise-induced hyperalgesia

Timeframe: Immediately after the intervention

Trial details

NCT IDNCT05633225

SponsorVastra Gotaland Region

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2023-06-30