UnknownNot Applicable

Comparison of Clinical Outcomes in Fresh Cycle With Single Blastocyst Stage and Double Cleavage-stage Embryos: a Single-center, Non-blind, Randomized Controlled Study

1,236 participantsStarted 2022-12

Plain-language summary

In traditional assisted reproductive technology (ART), choosing multiple embryo transfer to get a high clinical pregnancy rate while increasing the risk of multiple pregnancies. Research showed that the single-cleavage embryo transfer could not simultaneously meet the dual requirements of maintaining pregnancy rate and reducing the multiple pregnancy rate.The purpose of this study was to observe the clinical outcome between double cleavage embryo transfers and single blastocyst transfers in fresh cycle through RCT study with GnRH antagonist protocol.

Who can participate

Age range18 Years – 38 Years

SexFEMALE

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Inclusion criteria

✓. patients with a diagnosis of primary or secondary infertility with a clinical indication for IVF/intracytoplasmic sperm injection (ICSI)
✓. under 38 years of age
✓. number of AFC≥6, AMH\>1.1ng/ml
✓. no adverse factors of fresh embryo transplantation (evaluation by an experienced reproductive physician)
✓. number of available embryos(day 3)≥4
✓. informed consent

Exclusion criteria

✕. PGT
✕. with adenomyosis, endometrial compression by uterine fibroids, intrauterine adhesion, endometrial polyps and other factors unsuitable for fresh cycle transplantation

What they're measuring

live birth rate per fresh transfer

Timeframe: 2 year

Trial details

NCT IDNCT05632731

SponsorWomen's Hospital School Of Medicine Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-08

Contact for this trial

Yimin Zhu, Dr

0571-89992071 zhuyim@zju.edu.cn

View on ClinicalTrials.gov More Infertility, Female trials