CompletedNot Applicable

Diagnostic Accuracy for Hemodynamically ICAS of MR-FFR Comparing With Pressure-wire-based FFR.

China42 participantsStarted 2019-06-18

Plain-language summary

The aim of this study was to determine the diagnostic accuracy of MR-FFR to detect functionally significant ICAS comparing with pressure-wire-based FFR.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patients aged 18 years or older.
✓. Patients with transient ischemic attack (TIA) or nondisabling ischemic stroke caused by a focal ICAS lesion located in intracranial anterior circulation (intracranial internal carotid artery and their major branches).
✓. 50% to 99% stenosis (calculated by modified WASID method) of responsible arterial occlusion, confirmed by digital subtraction angiography (DSA).
✓. Informed of the study protocol and objectives.

Exclusion criteria

✕. Non-atherosclerotic MCA stenosis
✕. Combined with moderate or severe stenosis of other extracranial and intracranial arteries
✕. Previous endovascular treatment or surgery for cerebrovascular diseases
✕. Large cerebral infarction (more than 1/2 MCA perfusion area)
✕. Combined with other neurological diseases, such as aneurysm, arteriovenous malformation, tumor, hydrocephalus, cerebral trauma, cerebral hemorrhage, multiple sclerosis, epilepsy and intracranial infection.
✕. Vascular abnormality or stunting, resulting in the impossibility of endovascular intervention
✕. Liver and kidney dysfunction, or severe allergy to the contrast agent
✕. Severe coagulation dysfunction

What they're measuring

Diagnostic accuracy of MR-FFR measurement.

Timeframe: 3 days

Trial details

NCT IDNCT05631470

SponsorXuanwu Hospital, Beijing

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-03-01

View on ClinicalTrials.gov More Stroke, Ischemic trials