Hypothalamic amenorrhea (HA) occurs during reproductive years and results in stopped menstrual cycles and infertility which can be prolonged from months to years and is characterized by varying combinations of psychosocial stress, anxiety, high levels of physical activity, and/or weight loss. Data from our group indicates that one-third of women with HA (mean age: 27 yrs) have preclinical cardiovascular disease (CVD) measured noninvasively as vascular dysfunction and vascular inflammation. This study will use HA as a marker of fertility status for cardiovascular health and perform dense-phenotyping using remote patient monitoring (FitBit) and patient reported outcomes (questionnaires) to determine which HA phenotypes are related to preclinical CVD and inflammation.
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Hypothalamic Amenorrhea (HA) duration
Timeframe: 3 months
Vascular dysfunction
Timeframe: 3 months
Psychosocial stress
Timeframe: 3 months
Perceived stress
Timeframe: 3 months
Step count
Timeframe: 3 months
Physical activity level
Timeframe: 3 months
Heart Rate
Timeframe: 3 months
Caloric intake and nutrition
Timeframe: 3 days
Vascular inflammation
Timeframe: 3 months