Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema

Inclusion Criteria: * Informed Consent signed by the subject * Patients discussed in the interdisciplinary emphysema treatment board and found to have the indication for a LVRS or patients who meet the criteria in agreement with pneumology recommendation for bilateral or unilateral LVRS with pulmonary emphysema (all morphologies including chronic obstructive pulmonary disease (COPD) GOLD III and IV) or patients operated for other Pathology other than lung emphysema requiring lung resection in the presence of severe lung emphysema. Exclusion Criteria: * non-bullous pulmonary emphysema * Severely impaired carbon monoxide diffusing capacity (≤ 20% of predicted value, One-second capacity (FEV1) ≤ 20% of predicted value with a homogeneous emphysema morphology * Patients with severe pulmonary arterial hypertension (mPAP \> 35 mmHg) and are symptomatic * Significant (i.e. clinically relevant and symptomatic) Coronary Arterial Disease (CAD) * Inability to follow the procedures of the study, e. g. due to language problems, psychological disorders, dementia, etc. of the participant * Enrolment of the investigator, his/her family members, employees and other dependent person * Current enrolment in another clinical trial studying an experimental treatment * Pregnancy