UnknownNot Applicable

Topical Ethanol Extract (Piper Crocatum) for Anogenital Warts

Indonesia100 participantsStarted 2022-11-30

Plain-language summary

This clinical trial aims to assess the efficacy of topical Piper crocatum in treating Anogenital warts. It aims to answer * the clinical efficacy of treating anogenital warts * the expression of Foxp3+ regulatory T (Treg), TGF/Tumor Growth Factor -β1, and IFN/interferon -γ of anogenital wart lesion Participants will be allocated into two topical treatments, intervention and active comparator Trichloroacetic Acid (TCA) 90%. The researchers assume that intervention is superior compared to TCA 90%

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Men and women diagnosed with external anogenital warts
✓. Clinical lesions of Anogenital Wart at least 3 lesions with a size of 1-5 cm
✓. In patients with HIV, Cluster of Differentiation 4 (CD4)cell count \>350 cells/mm and have been taking antiretroviral (ARV) drugs regularly for 3 months,

Exclusion criteria

✕. Pregnant or lactating women
✕. Lesions located in the external urethral orifice and vagina
✕. Using systemic immunomodulators/immunosuppressants

What they're measuring

Size of wart

Timeframe: Changes of wart size from baseline to week 12

Foxp3+ regulatory T (Treg)

Timeframe: change of Foxp3+ regulatory T (Treg) expression from baseline to week 8

TGF-β1

Timeframe: change of TGF-β1 expression from baseline to week 8

IFN-γ

Timeframe: change of IFN-γ expression from baseline to week 8

Trial details

NCT IDNCT05622916

SponsorHasanuddin University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-28

Contact for this trial

Idrianti Idrus, MD

+624118910174 rasiah.05@gmail.com

View on ClinicalTrials.gov More Anogenital Wart trials