UnknownNot Applicable

Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment

Austria392 participantsStarted 2022-03-21

Plain-language summary

As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis management. First aim of this study will be to evaluate the influence of TNF-alpha on Gram+ and Gram- bacteria causing keratitis. Second aim of this study will be to develop an algorithm, that should help to distinguish between different pathogens causing keratitis.

Who can participate

Age range18 Years – 119 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men and women age of at least 18 years to 119 years * Written informed consent prior to study-related procedures * First presentation with keratitis (corneal epithelial ulceration, corneal edema and/or stromal infiltration with inflammatory cells) within 10 days. * Untreated keratitis or keratitis not responding to the given treatment Exclusion Criteria: Subjects will be excluded if one or more of the following criteria apply: * Symptoms for more than 10 days * Presence or history of a severe medical condition as judged by the clinical investigator * Pregnancy, planned pregnancy or lactating

What they're measuring

TNF Alpha in Tear Film

Timeframe: The measurement is assessed at the point of study inclusion.

Trial details

NCT IDNCT05620264

SponsorJohannes Kepler University of Linz

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-04-30

Contact for this trial

Nino D Hirnschall, MD,PhD

004373278061510 nino.hirnschall@kepleruniklinikum.at

View on ClinicalTrials.gov More Keratitis Bacterial trials