Detection of Coronary Artery Calcifications by Whole Blood Transcriptome Analyzed by Artificial InTelligence Algorithms

Inclusion Criteria: * Men and women between 30 and 75 years attending the institution for a non-contrast cardiac CT scan (coronary calcium score) either by medical indication or voluntary for cardiovascular risk assessment. * Signature of the informed consent form Exclusion Criteria: * Previously known chronic renal or hepatic insufficiency. * Active chronic lung disease, defined as exacerbated asthma, exacerbated chronic obstructive pulmonary disease (COPD), or pulmonary fibrosis. * Active and/or previous cardiovascular disease, defined as previous acute myocardial infarction, stable or unstable angina, cerebrovascular accident, history of vascular interventions (coronary or another territory), heart failure, severe cardiomyopathies, or valvulopathies. * Uncontrolled hyper or hypothyroidism. * Suprarenal insufficiency. * Previous surgeries in the last 3 months. * Severe trauma in the last 6 months, defined as one that involved bone fractures and/or surgical interventions. * Known active cancer disease or under treatment (acute or preventive), or history of cancer disease without criteria for a cure. * Known autoimmune disease active or in treatment. * Ongoing pregnancy, postpartum period of fewer than 12 months, or breastfeeding. * Other serious illnesses with an estimated life expectancy of fewer than 12 months (according to the investigators). * Temperature greater than 37.5°C recorded by a thermometer or any acute infection caused by viruses or bacteria confirmed by a …