Salicylic Acid Versus Cryotherapy for the Treatment of HPV1-induced Plantar Warts

Inclusion Criteria: * Patients with HPV1-induced plantar warts. * Total number of warts is ≤5. * Aged 12 years or older. Exclusion Criteria: * Patients are currently participating in another trial for the treatment of plantar warts. * Patients had received two or more consecutive sessions of cryotherapy, with an interval of no more than 4 weeks (The history of salicylic acid treatment was not considered as criteria for exclusion because high concentration salicylic acid is not commercially available in Chinese mainland). * Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months. * Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism. * Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases). * Patients are pregnant or ready for pregnancies or breast-feeding. * Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome). * Patients have local pain intolerance. * Patients have local hypoesthesia. * Patients are unable to tolerate salicylic acid or cryotherapy.