Intervention on Bone Health in Wheelchair Users (NCT05615402) | Clinical Trial Compass
CompletedNot Applicable
Intervention on Bone Health in Wheelchair Users
Norway45 participantsStarted 2022-12-01
Plain-language summary
The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD). Adding mechanical loading through physical activity in combination with optimizing nutrition may counteract these negative consequences in wheelchair users and thereby provide positive impact for bone health, as well as for physical and mental health.
In this project, a multidisciplinary team will tailor a bone-specific exercise and nutrition program to increase BMD in sport active and non-active wheelchair users with initial low BMD.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion Criteria:
* BMD Z-score of the spine ≤ 0 SD
* primary aid for mobility being a manual wheelchair, i.e. ≥50% of the time
* 18-60 Y
* congenital (i.e., CP, spina bifida, dysmelia, hip dysplasia) and acquired disabilities (i.e., SCI, amputation)
* non-progressive impairment, and in the case of SCI; ≥ 2 years since time of injury
* ability to perform key exercises (e.g., overhead press)
Exclusion Criteria:
* injury acquired \<2 Y ago
* change in health and/or medication within the last 3 months
* fractures affecting measured sites or contraindicating strength testing/training
* menopausal, pregnancy or planned pregnancy during the study period
* language or cognitive barriers affecting the ability to understand all aspects of the study
* • patients with progressive neurological disease, serious or uncontrollable epilepsy, endocrine diseases (including diabetes mellitus type 1 or 2, thyroid disorders, calcium homeostasis disorders and metabolic bone disease, pituitary gland disorder, sex hormone disorders), cancer, serious mental disorder, or comorbid medical conditions affecting either a) nutritional function: i.e., malabsorption problems due to previous surgery in the gastrointestinal tract, inflammatory bowel disease, coeliac disease, eating disorders, chronic pancreatitis, liver or kidney disease (those that cannot convert vitamin D to its active form in the body), other conditions affecting vitamin D or calcium absorption; b) musculoskeletal system: i.e., congeni…