In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort group and healthy subjects group. Firstly, DTI probabilistic tracking method was used to detect the changes of the brain white matter in each group. Then, the low-frequency amplitude (mfalff) and local consistency (ReHo) of each group were compared by fMRI scanning imaging technology, and the features of local brain functional connectivity (FC) of pain matrix related brain regions as seed points were analyzed. Finally, MRS Technique was used to detect the brain signals of related metabolites glutamic acid (Glu) and 1-aminobutyric acid (GABA), so as to elucidate the network regulation of lever-positioning operation on the analgesic brain effect of LDH and the biochemical mechanism of central nervous system. This multimodal MRI technique provides biological basis for the clinical application of lever localization in LDH.
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visual analogue scale (VAS)
Timeframe: up to one month
Japanese Orthopaedic Association Scores (JOA)
Timeframe: up to one month
Amplitude of Low-Frequency Fluctuation (ALFF)
Timeframe: up to one month
Regional Homogeneity (ReHo)
Timeframe: up to one month
Functional Connectivity (FC)
Timeframe: up to one month
Diffusion Tensor Imaging (DTI)
Timeframe: up to one month
Magnetic Resonance Spectrum （MRS）
Timeframe: up to one month