RecruitingNot Applicable

Confounding Factors of Chronic Endometritis in Women With Reproductive Failure

Hong Kong720 participantsStarted 2023-01-26

Plain-language summary

The aim of the study is to investigate the confounding factors of chronic endometritis and therapeutic benefits of antibodies targeting plasma cells in women with reproductive failure.

Who can participate

Age range20 Years – 45 Years

SexFEMALE

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Inclusion criteria

✓. Age 20-45 years;
✓. Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation12; or
✓. Women who failed to conceive after unprotected intercourse for one year; or
✓. Women who failed failure to achieve a clinical pregnancy after two consecutive cycles of IVF, ICSI or frozen embryo replacement cycles where the cumulative number of transferred embryos is no less than four for day-2 embryos and no less than 2 for day-5 embryos (blastocysts), with all embryos being of good quality.

Exclusion criteria

✕. Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural);
✕. Untreated hydrosalpinx;
✕. History of antiphospholipid syndrome;
✕. Known clinical autoimmune disease;
✕. Undergoing immunotherapy;
✕. Abnormal thyroid function;
✕. Abnormal karyotyping.
✕. Those with active pelvic inflammatory disease or suspicion of infection etc.

What they're measuring

Live birth rate

Timeframe: 31 December 2027

Trial details

NCT IDNCT05613049

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-07-31

Contact for this trial

Stacey Wong, BSc

35051764 staceywong@cuhk.edu.hk

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