Evaluation of AL Prediction for Rectal Cancer (NCT05610904) | Clinical Trial Compass
UnknownNot Applicable
Evaluation of AL Prediction for Rectal Cancer
China418 participantsStarted 2022-12-10
Plain-language summary
Anastomotic leakage is one of the most serious postoperative complications of low rectal cancer, with an incidence of 3%-21%. The occurrence of anastomotic leakage is related to many factors, and the occurrence of anastomotic leakage can be predicted by building a prediction model. Most of the anastomotic leakage prediction models constructed in the past are nomograms, which have limitations in the fitting of model creation. In the previous study, the center took the lead in building a random forest anastomotic leakage prediction model based on machine learning. This study intends to prospectively enroll patients with rectal cancer undergoing anterior abdominal resection and use their clinical data to prospectively verify the efficacy of the anastomotic leakage prediction model, and further improve and promote the prediction model.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Patients aged 18-75 years
✓. Adenocarcinoma confirmed by pathology
✓. Colonoscopy or imaging examination confirmed that the distance between the lower edge of the tumor and the anal edge was less than or equal to 12cm
✓. Preoperative imaging diagnosis was cTxNxM0
✓. No local complications (no obstruction, incomplete obstruction, no massive active bleeding, no perforation, abscess formation, and no invasion of adjacent organs)
✓. The hematopoietic functions of heart, lung, liver, kidney and bone marrow meet the requirements of surgery and anesthesia
✓. Voluntarily sign the informed consent form
Exclusion criteria
✕. Previous history of malignant tumor
✕. Simultaneous multiple primary colorectal cancer