In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Perceptâ„¢ primary cell (PC) Neurostimulator DBS System with BrainSenseâ„¢ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimulation and informed by network architecture in patients with epilepsy that arises in a hippocampus that also subserves memory - epilepsy in a precious hippocampus (EPH) - will result in a significant decrease in seizure frequency and severity, paralleled by a decrease in EEG spike counts and improved memory function.
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Number of seizures as self-reported by participants
Timeframe: baseline
Number of seizures as self-reported by participants
Timeframe: 2 weeks
Number of seizures as self-reported by participants
Timeframe: 4 weeks
Number of seizures as self-reported by participants
Timeframe: 6 weeks
Number of seizures as self-reported by participants
Timeframe: 8 weeks
Number of seizures as self-reported by participants
Timeframe: 10 weeks
Number of seizures as self-reported by participants
Timeframe: 12 weeks
Number of seizures as self-reported by participants
Timeframe: 14 weeks
Number of seizures as self-reported by participants
Timeframe: 16 weeks
Number of seizures as assessed by EEG
Timeframe: baseline
Number of seizures as assessed by EEG
Timeframe: 4 months
Number of seizures as assessed by the Percept PC
Timeframe: baseline
Number of seizures as assessed by the Percept PC
Timeframe: 4 months
Number of inter-ictal spikes as assessed by the Percept PC
Timeframe: baseline
Number of inter-ictal spikes as assessed by the Percept PC
Timeframe: 4 months