In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimulation and informed by network architecture in patients with epilepsy that arises in a hippocampus that also subserves memory - epilepsy in a precious hippocampus (EPH) - will result in a significant decrease in seizure frequency and severity, paralleled by a decrease in EEG spike counts and improved memory function.
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of seizures as self-reported by participants
Timeframe: baseline
Number of seizures as self-reported by participants
Timeframe: 2 weeks
Number of seizures as self-reported by participants
Timeframe: 4 weeks
Number of seizures as self-reported by participants
Timeframe: 6 weeks
Number of seizures as self-reported by participants
Timeframe: 8 weeks
Number of seizures as self-reported by participants
Timeframe: 10 weeks
Number of seizures as self-reported by participants
Timeframe: 12 weeks
Number of seizures as self-reported by participants
Timeframe: 14 weeks
Number of seizures as self-reported by participants
Timeframe: 16 weeks
Number of seizures as assessed by EEG
Timeframe: baseline
Number of seizures as assessed by EEG
Timeframe: 4 months
Number of seizures as assessed by the Percept PC
Timeframe: baseline
Number of seizures as assessed by the Percept PC
Timeframe: 4 months
Number of inter-ictal spikes as assessed by the Percept PC
Timeframe: baseline
Number of inter-ictal spikes as assessed by the Percept PC
Timeframe: 4 months