Background. An increase in inflammatory biomarkers is associated with impaired kidney function and increased cardiovascular risk and mortality. Physical exercise has been shown to improve the functional capacity and inflammatory status of patients undergoing hemodialysis (HD) treatment, increasing their health-related quality of life. Virtual reality (VR) is an effective and safe tool to increase patient adherence to the exercise program, however, there are very few studies that analyze its effect on the functional capacity of patients with chronic kidney disease (CKD) in HD and none analyze its effect on the inflammatory state of these patients, which justifies the performance of this study. Methods. Eighty patients with CKD on HD treatment will be randomly assigned into two groups, one of them will perform an intradialysis exercise program with non-immersive VR (intervention group; n=40), and the other will exercise with a static pedal (control group; n). =40). The functional capacity of the patients and their inflammatory and psychological status, as well as their exercise adherende, will be analyzed before and after exercise programs.
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Change of Interleuquine 6 (IL-6) (pg/ml)
Timeframe: Change from Baseline IL-6 at 12 weeks
Change of Tumoral Necrosis Factor-alpha (TNF-alpha) (pg/ml)
Timeframe: Change from Baseline TNF-a at 12 weeks
Change of C Reactive Protein (CRP) (mg/L)
Timeframe: Change from Baseline CRP at 12 weeks
Change of Intercellular Adhesion Molecule 1 (ICAM 1) (ng/ml)
Timeframe: Change from Baseline ICAM 1 at 12 weeks
Change of Vascular cell adhesion protein 1 (VCAM 1) (ng/ml)
Timeframe: Change from Baseline VCAM 1 at 12 weeks