Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction

Inclusion Criteria: * Myocardial infarction with elevation of the ST segment of the ECG (at point J) in 2 adjacent leads after no more than 6 hours from the onset of pain (lasting at least 20 minutes) in the chest (at the time of screening): * ≥ 2.5 mm in male ˂ 40 years, ≥ 2 mm in male ≥ 40 years, or ≥ 1.5 mm in female in leads V2-V3 and/or * ≥ 1 mm in other leads in the absence of left ventricular hypertrophy or left bundle branch block. Exclusion Criteria: * Diseases accompanied by significant bleeding, currently or within the last 6 months, hemorrhagic diathesis. * Current oral anticoagulant therapy with INR \> 1.3. * Diseases of the central nervous system at present or in history (neoplasm, aneurysm, surgery on the brain or spinal cord). * Severe uncontrolled arterial hypertension. * Major surgical interventions, biopsy of a parenchymal organ or significant trauma within the last 2 months (including trauma in combination with AMI at the present time), recent (within the last 3 months) traumatic brain injury. * Prolonged or traumatic cardiopulmonary resuscitation (\> 2 minutes) within the last 2 weeks. * Severe liver dysfunction, including liver failure, cirrhosis, portal hypertension (including esophageal varicose veins), active hepatitis. * Peptic ulcer of the stomach or duodenum in the acute stage. * Chronic kidney disease or other significant kidney disease with a decrease in glomerular filtration rate ≤30 ml / min / 1.73 m2. * Arterial aneurysm or presence of…