Repetitive Transcranial Magnetic Stimulation in Hemiplegic Shoulder Pain (NCT05601921) | Clinical Trial Compass
CompletedNot Applicable
Repetitive Transcranial Magnetic Stimulation in Hemiplegic Shoulder Pain
Turkey (Türkiye)18 participantsStarted 2022-10-01
Plain-language summary
Shoulder pain after stroke is one of the most common complications of stroke. Underlying mechanisms of shoulder pain after stroke still completely is not clarified. Central sensitization and neuropathic pain mechanisms are thought to play a role in the etiology of pain. Research on repetitive transcranial magnetic stimulation therapy in the treatment of pain in which somatosensory sensitization mechanisms play a role is increasing day by day. There are studies showing that application of high-frequency rTMS to the primary motor cortex provides effective pain relieving in most of painful conditions. However, data in the literature regarding the application of high-frequency rTMS in shoulder pain after stroke are very limited. There is only one clinical study related to this. More studies are needed in this area.In our study, it was aimed to examine the effects of this treatment protocol applied on the effects of pain on daily activities, upper extremity disability, anxiety, depression, range of motion and neurophysiological parameters.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Being between the ages of 18-70
* Presence of ischemic or hemorrhagic stroke confirmed by MRI
* Having a stroke for the first time
* Presence of stroke in the subacute or chronic period
* Presence of subacute or chronic shoulder pain starting after stroke and Numeric Rating Scale \>4
* If the patient is receiving analgesic treatment, the pain persists despite at least one week of analgesic treatment.
* Patients who agreed to participate by signing the informed permission form.
Exclusion Criteria:
* Presence of history of surgical intervention on the shoulder joint
* Presence of history of peri/intraarticular injection into the shoulder joint
* Rotator cuff injury or tendonitis, frozen shoulder, etc. that they had diagnosed/treated before stroke
* Presence of full-thickness rotator cuff tear visualized by US
* Presence of \>3 spasticity in the upper extremity defined according to the Modified Ashworth Scale
* Presence of severe cognitive impairment
* Presence of aphasia
* History of malignancy or systemic rheumatic disease
* Alcohol or drug addiction
* History of psychiatric illness such as major depression/personality disorders
* History of epilepsy or taking medication due to epilepsy
* Diagnosed with dementia
* Pregnancy and breastfeeding
* Having received TMS treatment before
* Having a clinical condition (metallic implant, cardiac pace, head trauma, cranial operation history…) that would be a contraindication for TMS
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from baseline in the Numeric Rating Scale
Timeframe: (1) at the beginning of the treatment, (2) at the 1st week, (3) at the 2nd week, (4) at the end of the treatment (3rd week), (5)one month after the end of the treatment