Remote Ischemic Conditioning and Dynamic Cerebral Autoregulation in Patients With Intracranial an… (NCT05599009) | Clinical Trial Compass
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Remote Ischemic Conditioning and Dynamic Cerebral Autoregulation in Patients With Intracranial and Extracranial Arteriosclerosis
China140 participantsStarted 2022-12-10
Plain-language summary
The purpose of this study is to explore the effect of remote ischemic conditioning on the dynamic cerebral autoregulation in patients with intracranial and extracranial arteriosclerosis and the changes of dynamic cerebral autoregulation within 24 hours after remote ischemic conditioning.
Who can participate
Age range18 Years – 79 Years
SexALL
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Inclusion criteria
✓. Age≥18 years, \< 80 years, regardless of sex;
✓. Patients with clinically definite diagnosis of intracranial and extracranial atherosclerosis.
✓. Baseline Glasgow Coma Scale (GCS) ≥8;
✓. Be able to accept remote ischemic conditioning;
✓. Bilateral temporal windows were well penetrated;
✓. Signed and dated informed consent is obtained
Exclusion criteria
✕. Patients who undergo intravenous thrombolysis or endovascular treatment;
✕. Patients with consciousness disorder or restlessness who cannot cooperate with dynamic cerebral autoregulation;
✕. Patients whose stable cerebral blood flow velocity envelope cannot be obtained by transcranial Doppler ultrasound or whose cerebral blood vessels have not been detected;
✕. Patients with severe arrhythmia (frequent ventricular or supraventricular arrhythmia diagnosed by 24 hours dynamic ECG), hyperthyroidism, severe anemia, unstable blood pressure and other factors affecting the hemodynamics;
✕. Other intracranial lesions, such as cerebrovascular malformations, cerebral venous lesions, tumors and other diseases involving the brain craniocerebral planning for surgical treatment;