Denosumab vs Zoledronate After Vertebroplasty

Inclusion Criteria: * Must be age between 50 and 90 years old * X-ray diagnosis of 1 or 2 segment vertebral compression fractures from T4 to L5 * Bone mineral density T value less than -1 via dual-energy X-ray * A recent fracture history less than 6 weeks * MRI show bone marrow edema of fractured vertebrae * low back pain, local paravertebral tenderness Exclusion Criteria: * Must be able to have no intervertebral fissure * Must be able to have no infection * Must be able to have no malignancy * Must be able to have no neurological dysfunction * Must be able to have no previous use of anti-osteoporosis drugs * Must be able to have no inability to perform magnetic resonance imaging * Must be able to have no prior back open surgery * Must be able to have no other established contraindications for elective surgery