This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.
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Change in 3D-CAM to assess postoperative delirium (POD)
Timeframe: Assessed daily on postoperative days 0 to 7 (or up to discharge, whichever occurs earlier)
Change in Confusion Assessment Method for the ICU (CAM-ICU) to assess postoperative delirium (POD)
Timeframe: Assessed daily on postoperative days 0 to 7 (or up to discharge, whichever occurs earlier)