Donation of Whole Blood by Healthy Volunteers After Mobilisation by Haematopoietic Growth Factor (Rhu-G-CSF = Granocyte)

Inclusion Criteria: * Healthy male volunteers, * Age ≥ 18 years and ≤ 60 years, * Agreeing to the collection of blood products by whole blood donation for scientific research purposes, * Fit for collection by the collecting physician after a medical examination including measurement of blood pressure, heart rate, electrocardiogram and assessment of venous potential, * Minimum weight: 50 kg, * Body mass index (BMI) \< 30, * Haemoglobin level between 13 g/dL and 18 g/dL, * Platelet count between 150.106/mL and 400.106/mL * White blood cell count ≥ 3.9.106/mL with neutrophils ≥ 2.5.106/mL, * Agreement to be registered in the national research file, Exclusion Criteria: * Any cardiopulmonary abnormality on initial clinical and ECG assessment * Clinical measurement of systolic BP ≤ 110 mmHg and/or diastolic BP \< 70 mmHg on initial workup * Any blood work-up abnormality deemed significant by the investigator at the time of the initial work-up, * Previous administration of any haematopoietic growth factor, * Regular use of medication(s) within 8 days prior to the start of the Granocyte mobilisation phase, * Any significant cardiovascular history within the last 2 years * Any history of severe pulmonary disease (including bacterial or viral pneumonia) * Any history of cancer (solid tumours or haematological malignancies) * Anysevere neurological history * Any severe psychiatric history * Renal history (creatinine clearance from stage 1 to stage 5 of the HAS 2012 classification) * …