CompletedNot Applicable

Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates

Egypt60 participantsStarted 2022-10-27

Plain-language summary

A randomized controlled clinical trial evaluates cerebral blood flow changes associated with HFOV-VG in comparison to HFOV alone in preterm neonates with respiratory insufficiency during the period of invasive respiratory support

Who can participate

Age range1 Day – 1 Month

SexALL

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Inclusion criteria

✓. Preterm neonates with gestational age ≤ 35 weeks.
✓. Neonates with various causes of respiratory failure: respiratory distress syndrome (RDS), air leak syndromes, pneumonia, or pulmonary hemorrhage, failing with conventional ventilation (i.e. when conventional ventilation failed to maintain either oxygenation or ventilation) and are switched to HFOV as a rescue therapy.

Exclusion criteria

✕. Preterm neonates with major upper or lower airway anomalies.
✕. Preterm neonates with significant congenital anomalies including cardiac, abdominal or respiratory

What they're measuring

Doppler cerebral blood flow velocity measurements

Timeframe: 72 hours

Trial details

NCT IDNCT05592431

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-30

View on ClinicalTrials.gov More Infant, Premature, Diseases trials